Side-Effect-Free Hair Treatment: Why CALECIM® Is the Non-Surgical Option You Need for Hair Growth

Hair loss treatments are frequently restricted by systemic side effects, compliance issues, or invasive procedures. The CALECIM® Advanced Hair System (AHS) provides a powerful, non-hormonal, and non-surgical alternative by leveraging patented regenerative biotechnology to address the underlying cellular environment of hair loss.

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Side-Effect-Free Hair Treatment: The PTT-6® Core Answer

The CALECIM® Advanced Hair System (AHS) is a safe, non-surgical treatment that helps improve hair health by applying PTT-6®, a powerful rejuvenating substance, directly to the scalp to encourage natural cell growth

The Advanced Hair System’s strong efficacy and safety profile are based on its unique scientific foundation:

• Mechanism of Action: PTT-6® is derived from ethically sourced cord lining stem cells and contains over 3,000 messaging signals, including growth factors, cytokines, peptides, and exosomes, that stimulate local follicle cells to behave younger. 
• Superior safety: Clinical studies have reported no adverse events, and the treatment has been confirmed to be dermatologically safe. The formula is completely hormone-free, which eliminates the systemic side effects associated with oral anti-androgens. 
• Quantitative Efficacy: A 12-week clinical case series by Dr. Nikolaus Duschek, M.D., PhD., Yuvell Clinical Trial Center, Vienna, Austria, demonstrated a significant increase in both the quantity and quality of hair: 
  • 14% increase in total hair count 
  • 16% increase in hair shaft thickness 
  • 15% increase in the number of active follicular units per square centimeter (sqcm) 
• Optimized Environment: The regenerative complex provides a powerful anti-inflammatory effect, achieving a notable 30-fold reduction in inflammatory markers around hair follicles. This addresses a primary cause of follicle cell death in pattern baldness. 
• Timeline: While optimal results are measured after the 12-week program, visible benefits, such as a noticeable decrease in shedding and scalp inflammation, can often be observed within the first  6 weeks of treatment. 

PTT-6® vs. Conventional Agents: Comparing Regenerative and Pharmacological Solutions

Choosing the right hair restoration therapy involves evaluating the mechanism of action, potential side effects, and required patient compliance. CALECIM® AHS offers a regenerative approach that contrasts sharply with traditional pharmacological and invasive treatments.

The Regenerative Advantage of Stem Cell Secretome

Unlike minoxidil, which primarily increases blood flow, or finasteride, which blocks the hormonal pathway, Calecim PTT-6® provides over 3,000 distinct signals that initiate biological restoration. Laboratory studies show that PTT-6® stimulates hair follicle cell growth by  24%, matching the cellular activation potential of minoxidil in controlled conditions, but achieves this through a distinct regenerative signaling pathway. 

The Advanced Hair System Protocol: A Step-by-Step Guide to Topical Regeneration

The CALECIM® Advanced Hair System protocol is structured for maximum compliance and delivery, requiring only twice-weekly application during the intensive phase.

Regimen Quick-Specs

Step 1: Scalp Preparation and Micro-Channeling

Before applying, wash your hair and sterilize the activator, such as a derma stamper or dermaroller. Use the activator along the length of the parting in the target areas, typically 2–3 times. This minimally invasive step creates micro-channels, facilitating effective serum delivery past the stratum corneum and ensuring that the regenerative PTT-6® can reach the hair follicles. 

Step 2: Topical Application of PTT-6®

Open the ampoule and apply half a vial of the Advanced Hair System directly to the micro-channeled treatment area. This application delivers the high concentration of stem cell-derived growth factors and exosomes needed to reactivate dormant hair follicles, strengthen existing strands, and protect against inflammatory stressors that cause hair damage.

Step 3: Distribution and Post-Care

Massage the serum into the scalp for a minimum of four minutes. This mechanical action ensures the PTT-6® is thoroughly distributed across the treatment area. To optimize the absorption and regenerative activity of the conditioned media, it is essential to refrain from washing the hair for a minimum of eight hours, and ideally for 24 hours.

Safety Note: The CALECIM® Advanced Hair System is gentle and well-tolerated, with no known side effects reported in clinical studies. However, the treatment is not suitable for individuals with active scalp conditions such as skin sores, rashes, pimples, cysts, hives, or infections. It is also contraindicated for individuals who are pregnant or breastfeeding. Always consult with a physician or clinician before starting any new hair treatment. 

Regenerative Success: Efficacy in Non-Responders and Complex Alopecia

The multi-modal signaling and anti-inflammatory properties of PTT-6® address the underlying pathogenesis of hair loss, making it a viable option even for complex or refractory cases where conventional, single-target therapies have failed. 

Treating Minoxidil Non-Responders

Specialists, including Scalp Technician Kelly Morrell, have reported that the CALECIM® Advanced Hair System produces excellent results in patients who were previously unresponsive to minoxidil. This clinical observation suggests that PTT-6®’s mechanism, which includes 24% increased cellular proliferation and a 30 times reduction in inflammation, addresses root causes of hair loss that simple vascular stimulation alone cannot resolve. 

Efficacy in Complex Stress-Related Hair Loss

The Calecim Advanced Hair System has shown promise in challenging, inflammation-driven conditions. A case report published in PubMed Central detailed a patient with severe chronic telogen effluvium induced by COVID-19. After showing minimal response to conventional daily minoxidil, the commencement of monthly applications of the Calecim serum led to effective regrowth of scalp hair. This third-party documented outcome validates the system’s role as an effective salvage therapy for refractory alopecia. 

Frequently Asked Questions (FAQ)

Q1. Is CALECIM® AHS hormone‑free and non‑systemic?
 Yes. The active, PTT‑6® conditioned media is 100% hormone‑free and works locally through cell signaling rather than systemic hormonal blockade.

Q2. When will I see results?
Inputs show a 6-week validated efficacy window for early signs, such as less shedding and a calmer scalp. A 12-week case-series result of a 14% increase in hair count, more than 16% thickness, and up to 15% density.

Q3. Can AHS help if Minoxidil didn’t?
Yes. Calecim AHS targets multiple pathways, including angiogenesis, anti-inflammatory control, and cell cycle signaling. It has demonstrated success in Minoxidil non-responders, including a COVID-19-induced TE salvage case.